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FasX small RNA
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FasX small RNA : ウィキペディア英語版
FasX small RNA
In molecular biology, the FasX small RNA (fibronectin/fibrinogen-binding/haemolytic-activity/streptokinase-regulator-X) is a non-coding small RNA (sRNA) produced by all group A ''Streptococcus''. FasX has also been found in species of group D and group G ''Streptococcus''. FasX regulates expression of secreted virulence factor streptokinase (SKA), encoded by the ''ska'' gene. FasX base pairs to the 5' end of the ska mRNA, increasing the stability of the mRNA, resulting in elevated levels of streptokinase expression. FasX negatively regulates the expression of pili on the bacterial cell surface. It binds to the 5' untranslated region of genes in the FCT-region in a serotype-specific manner, reducing the stability of and inhibiting translation of the pilus biosynthesis operon mRNA by occluding the ribosome-binding site through a simple Watson-Crick base-pairing mechanism.
==See also==

*Bacterial small RNA

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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